Tadalafil vs Sildenafil: Which is better to treat ED?

Erectile Dysfunction (ED) is the inability of a man to get and maintain an erection.

While occasional issues in erection are common, repeated episodes can result from a disorder.

The standard treatments of ED include PDE5 inhibitors like Sildenafil and Tadalafil.

Doctors primarily prescribe these FDA-approved salts for ED treatment.

While both are safe and effective medications for Erectile Dysfunction, they act differently in certain instances.

Despite their differences, both Sildenafil and Tadalafil have a high success rate.

Here, in the article we are answering the war of ED pills, Tadalafil vs Sildenafil

What are Tadalafil and Sildenafil?

Tadalafil and Sildenafil are FDA-approved medications used as oral medicines to treat erection issues.

They belong to the drug class called Phosphodiesterase inhibitors(PDE5 inhibitors).

In men, sexual stimulation causes nitric oxide production in the penile region.

Nitric Oxide is responsible for stimulating the production of cyclic Guanosine Monophosphate (cGMP) enzymes.

This cGMP enzyme causes erection by enhancing the blood flow through the penis.

PDE5 is an enzyme that breaks cGMP and restricts blood flow through the penis, causing the inability to gain an erection.

Tadalafil and Sildenafil are PDE5 inhibitors that restrict the breakdown of cGMP.

Which came first, Sildenafil or Tadalafil?

Sildenafil was the first ED oral treatment approved by the US Food and Drug Administration.

Pfizer introduced it in 1998 as Viagra, and in 2003 it started selling as Sildenafil Generic.

The active ingredient in generic Sildenafil is precisely the same as the brand Viagra.

The salt Sildenafil is available in prescription-based medicines such as Cenforce and Phallus Power.

Tadalafil was approved by the FDA in 2003 as a new ED medication and was introduced by the pharmaceutical company Eli Lilly under the brand name Cialis in the same year.

Since 2017, it has been available as a generic medicine and has the same contents as Cialis.

Tadalafil is available in prescription-based medicines like Tadarise 20 mg and Vidalista.

Hence, in Sildenafil vs Tadalafil, the former is the older one.

Tadalafil vs Sildenafil: Which lasts longer?

ED Medicines

Tadalafil can keep working for up to 36 hours, while Sildenafil works only for up to 4 hours.

Tadalafil 2.5mg and 5mg (Tadalafil daily) can be taken daily and is best for people with more than two sexual encounters per week.

Which of the two has a quicker action?

In Tadalafil vs Sildenafil, the former works faster – between 20 and 30 minutes after you take it.

Sildenafil works between 30 and 60 minutes after consumption.

The effectiveness of the medicines depends on how the individual reacts to each treatment.

Does food affect their actions?

Action of food on medicine

Sildenafil’s action gets delayed if consumed immediately after food; however, the same is not true for Tadalafil.

Sildenafil usually starts to act after 30 minutes of consumption.

The benefits of Sildenafil may be affected if you have a large, fatty, or high-calorie meal.

Although it’s best to take Sildenafil on an empty stomach, a light meal before taking medicine won’t impact much.

Contrarily, Tadalafil usually begins to function 20 minutes after consumption, and food has no impact on its effectiveness.

It’s advised to keep alcohol consumption to a maximum of one or two drinks because it might cause problems with ED medicines.

Drinking alcohol in any amount while taking these sex pills can reduce their effectiveness or cause health problems connected to high blood pressure.

Are there any side effects of Tadalafil and Sildenafil?

Tadalafil and Sildenafil have side effects, but not so much that one should avoid taking these ED pills.

Sildenafil’s side effects are headache, nausea, etc., which are usually common and are attributed to such ED medicines.

They also tend to stay for much less time.

Tadalafil’s side effects are not so common – most users experience Diarrhea, stomach ache, etc.

Since Tadalafil stays in your system longer, it might cause more side effects.

Headaches are a common side effect of both.

Sildenafil and Tadalafil in combination

Sildenafil and Tadalafil are both PDE5 inhibitors and act to lower blood pressure.

This is why, when used together, it can result in excessive blood pressure loss for the patient.

You should never mix ED medications on your own for fun, which is why even the FDA has not approved these medications to be used together.

What do women prefer?

The effects of Tadalafil on women are different from those of Sildenafil.

A study by Conaglen stated that women prefer Tadalafil-containing pills like Tadarise 20 mg more than Sildenafil-containing pills for their partners.

They stated that with Tadalafil, they felt more relaxed, experienced less pressure, and enjoyed a more natural or spontaneous sexual experience.

Tadalafil or Sildenafil – which one to choose?

Tadalafil is a better choice than Sildenafil because of its benefits for men who have Erectile Dysfunction.

While Sildenafil is more popular and less expensive, we recommend Tadalafil because it lasts longer and doesn’t get impacted by heavy meals.

Even if the personal choice is frequently based on experience, seeking any help should be your first step towards treating ED.

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Janet Fudge

Janet Fudge writes on general health topics for CheapMedicineShop.com. She holds a post-graduate diploma in Public Health with a major in epidemiology. During the outbreak of COVID-19, Janet actively volunteered in vaccination drives throughout the state of Iowa. She lives in Iowa with her husband and two children.