Is Lyrica A Safe Medicine?

Lyrica is a drug that is primarily used to treat neuropathic pain, a pain that occurs when any damage or an abnormality occurs to the nerves. Lyrica belongs to a group of medicines known as anticonvulsants and the active medical ingredient that is present in Lyrica is pregabalin. Lyrica is used in the treatment of various health problems such as:

  • Epilepsy – It is one of the common neurological disorders which is characterized by recurrent and unprovoked seizures. Seizures are of various types ranging from mild to serious.
  • Diabetic peripheral neuropathy – It is one of the complications of diabetes. Diabetes is a metabolic disorder that is characterized by high blood glucose levels. Uncontrolled diabetes causes diabetic peripheral neuropathy. High glucose level cause damage to nerves and causes symptoms such as loss of sensation, numbness, and tingling in the hands and legs.  
  • Fibromyalgia – It is a very common problem characterized by musculoskeletal pain and it is associated with various symptoms such as problems with sleep, memory, and excessive tiredness.
  • Postherpetic neuralgia – It is a chronic health condition that affects the nerve fibers and skin. It causes symptoms like rash, blisters, and burning sensation even when blisters disappear.

Multiple studies have been conducted to investigate the effect of Lyrica on the body of an individual. Lyrica works by controlling the chemicals in the brain that send signals to the nerves. It was observed by various researchers that Lyrica is associated with various side effects and complications. Consumption of Lyrica can cause many side effects ranging from mild to life-threatening.

Some of the common side effects of using Lyrica are as follows:

1. Edema

Edema is a health problem that is defined as a swelling that results from the collection of fluid in the spaces that surround the tissues in the body. In medical terms, edema is defined as a local or generalized condition in which the tissues in the body contain an excessive amount of tissue fluid.

Edema is characterized by the puffiness and stretching of the skin, and some of the most common sites of swelling include the lower leg, hands, and abdomen. There are various causes of edema, and consumption of certain medicines could also lead to the development of this disease, including Lyrica.

2. Constipation

Constipation is one of the most common side effects of various medicines and Lyrica is one of them. Constipation is very common and almost each one of us must have experienced it at least once in life. Constipation is a condition in which an individual face problem with bowel movements. Constipation is characterized by a small amount of hard and dry bowel movements, and it occurs at least thrice a week.

Constipation is associated with reduced quality of life. Apart from problems with bowel movements, constipation is accompanied by several other symptoms such as bloating, pain in the lower abdomen, and sluggishness.

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3. Xerostomia

Xerostomia, commonly known as dry mouth is an oral health problem that occurs due to the lack of production of saliva by the salivary glands. Saliva acts as a natural defense system for oral health and prevents tooth decay. Dry mouth is associated with various symptoms and problems.

Some of the common symptoms of dry mouth include a feeling of dryness in the mouth, mouth sores, cracked lips, a burning sensation in the mouth, and a rough tongue. Dry mouth is also associated with certain problems such as it causes difficulty in chewing, swallowing, and speaking, it increases the risk of infections, and increases the risk of dental problems. Dry mouth can have many causes, but it is considered to be a common side effect of Lyrica.

4. Dyspnea

Dyspnea is another common side effect of using Lyrica. Dyspnea is a medical term used for shortness of breath and it is associated with various distressing symptoms. Dyspnea generally occurs due to compromise in the cardiovascular or respiratory system, but it can also occur due to metabolic derangement, neurovascular disorders, and psychogenic conditions.

The three components that contribute to the occurrence of dyspnea are afferent signals, efferent signals, and central information processing. The central processing in the brain compares the afferent and efferent signals and when a mismatch occurs between the two, dyspnea occurs.

5. Hives

Hives are considered to be a common allergic reaction that can affect any part of the body. It is characterized by red and itchy patches, accompanied by swelling which usually disappears after some time. Hives are unpleasant but harmless. Hives are a sign of an allergy and they can be triggered by many things including medication, food, insect bites, chemicals, stress, and many other things. Medication is one of the common causes. There are various medicines that can trigger hives, and Lyrica is one of them. Hives are one of the side effects of Lyrica.  


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Janet Fudge

Janet Fudge writes on general health topics for She holds a post-graduate diploma in Public Health with a major in epidemiology. During the outbreak of COVID-19, Janet actively volunteered in vaccination drives throughout the state of Iowa. She lives in Iowa with her husband and two children.