5 Possible Causes Of Hypogonadism

Hypogonadism is a medical term which is used to describe a very low level of testosterone in the body and this lack of testosterone majorly affects the quality of life. Hypogonadism can be primary, secondary or the combination of both. Primary hypogonadism occurs due to the problem or the failure of the testes that produces testosterone and secondary hypogonadism occurs due to problems with the hypothalamus or the pituitary glands.

Hypogonadism can affect men of any age. Testosterone is an important steroid hormone that is involved in various body processes such as reproductive physiology, morphology, psychology, and behavior and each of these processes are involved in the normal functioning of the reproductive system. Testosterone is extremely important to maintain the sexual health of a man as it is not only vital for the growth of reproductive organs in males but it also enables a man to experience sexual desire and have an erection.

The symptoms of this disorder include decreased libido, impaired erectile function, weak muscles, depressed mood, and decreased vitality. Advancing age is the most common cause of testosterone but it is not the only cause of it. There are many other factors that can become a cause of hypogonadism or the lack of testosterone and some of the causes include:

1. Hemochromatosis

Hemochromatosis is a disorder which is defined as the toxic accumulation of iron and very high iron levels in the body can lead to low testosterone, low sex drive, and infertility. It is an inherited disorder that is characterized by an increased iron uptake from the gut and deposition of iron in the organs like liver, pancreas, heart and some tissues of the body as well.

A majority of people who are diagnosed with hemochromatosis also suffer from sexual dysfunction and lack of testosterone in the body is the significant cause of sexual dysfunction. Iron is deposited into the gonadotropins of the anterior pituitary gland that impairs the release of various hormones and leads to hypogonadotropic testicular failure and hence, loss of libido and impotence. 

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2. Klinefelter syndrome

Klinefelter syndrome is also known as 47,XXY and it is one of the most common sex chromosomal disorder that affects a large number of men. It results from X Chromosomes in males and it is the common cause of infertility and hypogonadism. Klinefelter affects the functioning of testicular.

Development and mal-development of testes in the Klinefelter syndrome begin in the fetal life and the loss of germ cells continues during infancy and accelerates through the puberty, causes conditions like fibrosis and hyperplasia of Leydig cells. It further results in the small firm testes and hypogonadism is a condition that occurs due to abnormalities in the testes.

3. Obesity

In the United States, obesity is one of the most common medical conditions and it is defined as an excessive weight gain that interferes with day to day activities. Obesity is highly associated with low testosterone level and it can be due to low sex hormone binding globulin in obese men.

There is a negative correlation between the body mass index and testosterone level and the relationship between them is complex. Sex hormone binding globulin decreases with an increasing obesity that results in the consistent decrease in the total testosterone level. The exact cause of low sex hormone binding globulin is not known yet but it is believed that it is associated with insulin resistance.

4. Diabetes Mellitus

Low level of testosterone has been reported in men with diabetes mellitus. In medical terms, diabetes mellitus is a chronic disorder that is characterized by insulin disorder, hyperglycemia, and glycosuria. In other words, diabetes mellitus is defined as a condition in which the blood glucose level of the body becomes too high. Sexual dysfunctioning is a common complication of uncontrolled diabetes and lack of testosterone is the common cause of dysfunctioning.

High blood glucose has a direct effect on the interaction between the endocrine system and the nervous system and it can result in the decrease in luteinizing hormone and follicle stimulating hormone due to the impairment in the production. Testosterone is primarily synthesized in Leydig cells which are regulated by luteinizing hormone and follicle stimulating hormone.

5. Thyroid disorders

Hyperthyroidism and hypothyroidism are the two most common types of thyroid disorder and various studies have suggested that hyperthyroidism and hypothyroidism are highly associated with the fluctuated level of hormones and infertility. Hyperthyroidism is defined as secretion of an excessive thyroid hormone and hypothyroidism is defined as lack of production of thyroid hormone by the thyroid gland.

Hypothyroidism can result in the reduction in the levels of sex hormone-binding globulin and a decrease in total testosterone level. It also leads to a decrease in luteinizing hormone and follicle-stimulating hormone that are closely related to the production of testosterone.



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Janet Fudge

Janet Fudge writes on general health topics for CheapMedicineShop.com. She holds a post-graduate diploma in Public Health with a major in epidemiology. During the outbreak of COVID-19, Janet actively volunteered in vaccination drives throughout the state of Iowa. She lives in Iowa with her husband and two children.